Abstract
A series of 2,4-diphenyl-1H-imidazole analogs have been synthesized and displayed potent human CB2 agonist activity. Many of these analogs showed high functional selectivity over human CB1 receptors. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these analogs are described.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Administration, Oral
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Animals
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Chronic Disease
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Humans
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Imidazoles / chemistry*
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Imidazoles / pharmacokinetics
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Imidazoles / therapeutic use
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Pain / drug therapy*
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Rats
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Receptor, Cannabinoid, CB1 / agonists
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Receptor, Cannabinoid, CB1 / metabolism
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Receptor, Cannabinoid, CB2 / agonists*
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Receptor, Cannabinoid, CB2 / metabolism
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Structure-Activity Relationship
Substances
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Imidazoles
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Receptor, Cannabinoid, CB1
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Receptor, Cannabinoid, CB2